Table 1

Concentrations of 1,25(OH)2D3 and ATRA causing a 50% inhibitory effect (ED50 m) in colony formation

MCF-7T-47DMDA-MB-231
1,25(OH)2D35.9 × 107.4 × 101.2 × 10
ATRA6.8 × 101.3 × 107.3 × 10
1,25(OH)2D3+ ATRA7.4 × 10a9.9 × 10a4.4 × 10
  • a Synergistic by Loewe’s Additivity Model (see text).