Table 2

Effects of preincubation with 1,25(OH)2D3a and ATRAa on the ED50 of paclitaxel and Adriamycin in colony formation assays

PaclitaxelAdriamycin
ED50 (m)Fold decreaseED50 (m)Fold decrease
MCF-7
Control4.8 × 109.8 × 10
1,25(OH)2D36.3 × 1076.26.9 × 1014.2
ATRA7.0 × 1068.69.1 × 1010.8
1,25(OH)2D3+ ATRA6.5 × 1073.88.3 × 1011.8
T-47D
Control6.0 × 108.4 × 10
1,25(OH)2D32.8 × 1021.43.3 × 102.5
ATRA1.0 × 1060.05.0 × 101.7
1,25(OH)2D3+ ATRA5.2 × 10115.42.4 × 103.5
MDA-MB-231
Control6.2 × 109.0 × 10
1,25(OH)2D39.6 × 1064.64.7 × 101.9
ATRA2.2 × 1028.25.1 × 101.8
1,25(OH)2D3+ ATRA1.8 × 1034.43.8 × 102.4
  • a 1,25(OH)2D3 and ATRA concentrations were 10−9 m each when used individually or in combination.