Table 1

Patient and tumor characteristics and TP53 mutation

TP53 gene status
No. of patients% mutatedP
All patients24337
Menopausal statusa
Premenopausal7041
Postmenopausal173350.37
Age (yr)a
<402564
40–557939
55–655829
>6581320.01c
Dominant site of relapse
Soft tissue3450
Bone11526
Visceral94460.003
Disease-free interval (mo)
<129049
>12153300.003
Prior adjuvant therapy
No20435
Yes39460.20
ER levels (fmol/mg protein)b
<106367
10–755836
>7512122<0.0001c
PgR levels (fmol/mg protein)b
<108257
10–756835
>7590190.0001c
  • a Age and menopausal status at start therapy.

  • b ER data are missing for one patient, but PgR data are present. PgR data are missing on three patients for whom ER data are available.

  • c Test for trend.