Presence of CD8+ T cells within esophageal tumors decreases with tumor progression
| Levels of CD8+ T cells were estimated in 70 patients after complete resection of primary esophageal carcinomas as described in “Materials and Methods.” Statistic analysis was performed using the χ2 test. Statistical significance was set at P < 0.05. Data in parentheses are percentages. | |||||
|---|---|---|---|---|---|
| CD8+ T cells | |||||
| Total primary tumors (70 cases) | No. of cases | i.t. | p.t. | SC/nil | P |
| pT Stagea | 0.008 | ||||
| pT1 | 13 | 4 (31) | 7 (54) | 2 (15) | |
| pT2 | 23 | 7 (30) | 4 (17) | 12 (52) | |
| pT3 | 28 | 0 (0) | 9 (32) | 19 (68) | |
| pT4 | 5 | 0 (0) | 1 (20) | 4 (80) | |
| Lymph node metastasisa | 0.015 | ||||
| pN0 | 23 | 7 (30) | 7 (30) | 9 (40) | |
| pN+ | 47 | 4 (8) | 15 (32) | 28 (60) | |
| Tumor gradinga | 0.040 | ||||
| Low | 6 | 3 (50) | 2 (33) | 1 (17) | |
| Moderate | 27 | 3 (11) | 9 (33) | 15 (56) | |
| High | 37 | 5 (13) | 11 (30) | 21 (57) | |
| Histotype | 0.112 | ||||
| Adenocarcinoma | 37 | 8 (22) | 8 (22) | 21 (56) | |
| SCC | 33 | 3 (9) | 14 (43) | 16 (48) | |
a Classified according to Tumor-Node-Metastasis classification. pT, tumor size; pN, lymph node involvement.