Table 2

ADCC of cultured human breast cancer cell lines

Cell line% Antibody-specific cytotoxicity
DF3 (%)DF3 × H22 (%)m520C9 (%)m520C9 × H22 (%)
ZR75-1a4.43.82.5NPb
MCF-7a4.35.1NPNP
SKBR-3c1.8NP63.653.1
  • a ZR75-1 and MCF-7 overexpress MUC-1 and do not express erbB-2.

  • b NP, assay not performed.

  • c SKBR-3 overexpress erbB-2 and do not express MUC-1.