Table 3

LOH frequencies of 12 polymorphic microsatellite markers at three stages of esophageal squamous neoplasia

Marker no.NameChromosome locationLow-grade dysplasiaaHigh-grade dysplasiaaInvasive cancera
 1D3S17663p14-p212/6 (33)5/6 (83)4/6 (67)
 2D3S45453p24.3-p250/5 (0)2/6 (33)5/6 (83)
 3D4S26324p12-p141/9 (11)3/10 (30)6/10 (60)
 4D8S11068p21.2-p23.30/7 (0)1/7 (14)3/7 (43)
 5D9S11189p11-q110/9 (0)3/9 (33)5/9 (56)
 6D9S9109q22.3-q312/2 (100)2/2 (100)2/2 (100)
 7GATA62F039p23-p240/7 (0)5/7 (71)5/7 (71)
 8D11S198411p15.3-p15.50/9 (0)3/9 (33)3/9 (33)
 9D13S149313q112/9 (22)5/10 (50)6/10 (60)
10D13S89413q12.3-q14.20/4 (0)1/4 (25)2/4 (50)
11D13S79613q32-q340/6 (0)1/6 (17)3/6 (50)
12D17S130317p11.2-p120/7 (0)3/7 (43)3/7 (43)
Totalb7/80 (9)34/83 (41)47/83 (57)
  • a No. of cases with LOH/number of informative cases (percentage).

  • b There is a statistically significant difference between low-grade dysplasia and both the high-grade dysplasia and invasive lesions in the frequency of LOH among the informative cases for all of the 12 markers combined (χ2; P < 0.001). However, the differences in LOH frequency among the histological grades for each marker were not statistically significant.