Distribution of MSI statusa in colon tumors by age and sex
| Age | Controls n (%) | MSI+ n (%) | MSI− n (%) | OR (95% CI) | χ2Pb MSI+ vs. MSI− | Interaction Pc for age and sex |
|---|---|---|---|---|---|---|
| Men | ||||||
| <50 | 131 (10.2) | 16 (13.3) | 53 (7.6) | 1.0 | ||
| 51–64 | 414 (32.1) | 34 (28.3) | 242 (34.5) | 0.5 (0.2–0.9) | ||
| 65–79 | 745 (57.7) | 70 (58.3) | 406 (57.9) | 0.5 (0.3–1.0) | 0.07 | |
| Women | ||||||
| <50 | 98 (8.7) | 10 (6.9) | 45 (8.3) | 0.8 (0.3–1.9) | ||
| 51–64 | 346 (30.9) | 38 (26.0) | 211 (38.9) | 0.6 (0.3–1.2) | ||
| 65–79 | 676 (60.4) | 98 (67.1) | 287 (52.8) | 1.2 (0.7–2.3) | <0.01 | <0.01 |
a MSI determined by 30% or more of 10 tetranucleotide markers unstable, BAT26 unstable, or TGFBRII unstable.
b χ2 Ps are for difference in proportion of MSI+ vs. MSI− tumors by age in men and in women separately.
c The P shows the interaction between gender and age as a risk factor for an MSI+ tumor.