Sex-specific associations with MSI+ tumors vs. control and MSI− tumors vs. control by tumor site
| Panel 12 | MSI+ vs. control | TGFβRII | MSI− vs. control | ||
|---|---|---|---|---|---|
| Panel 10 | Bat-26 | ||||
| Men/women N (%)a | 119 (14.6)/146 (21.3) | 96 (11.8)/111 (16.2) | 92 (11.3)/114 (16.6) | 81 (9.9)/111 (16.2) | 697 (85.4)/541 (78.7) |
| Men (referent) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Women (OR 95% CI)b | 1.7 (1.3–2.2) | 1.5 (1.1–2.1) | 1.8 (1.3–2.4) | 1.9 (1.4–2.6) | 1.0 (0.8–1.1) |
| Proximal tumors | |||||
| Men/women N (%) | 92 (22.4)/120 (33.7) | 76 (18.5)/94 (26.4) | 76 (18.5)/102 (28.7) | 67 (16.3)/98 (27.5) | 319 (77.6)/236 (66.3) |
| Men (referent) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Women (OR 95% CI) | 1.8 (1.4–2.5) | 1.7 (1.2–2.4) | 1.9 (1.4–2.6) | 2.1 (1.5–2.9) | 0.9 (0.7–1.1) |
| Distal tumors | |||||
| Men/women N (%) | 24 (6.2)/25 (7.9) | 18 (4.7)/16 (5.1) | 13 (3.4)/12 (3.8) | 11 (2.8)/13 (4.1) | 363 (93.8)/291 (92.1) |
| Men (referent) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Women (OR 95% CI) | 1.4 (0.7–2.5) | 1.1 (0.5–2.2) | 1.2 (0.5–2.8) | 1.5 (0.7–3.6) | 1.0 (0.8–1.2) |
a Number and percentage of cases with MSI+ and MSI− tumors for men and women.
b Adjusted for age, cigarette smoking, and alcohol consumption comparing risk MSI+ vs. control and MSI− vs. control. There are 1288 male controls and 1117 female controls.