Table 2

Sex-specific associations with MSI+ tumors vs. control and MSI− tumors vs. control by tumor site

Panel 12MSI+ vs. controlTGFβRIIMSI− vs. control
Panel 10Bat-26
Men/women N (%)a119 (14.6)/146 (21.3)96 (11.8)/111 (16.2)92 (11.3)/114 (16.6)81 (9.9)/111 (16.2)697 (85.4)/541 (78.7)
Men (referent)1.01.01.01.01.0
Women (OR 95% CI)b1.7 (1.3–2.2)1.5 (1.1–2.1)1.8 (1.3–2.4)1.9 (1.4–2.6)1.0 (0.8–1.1)
Proximal tumors
Men/women N (%)92 (22.4)/120 (33.7)76 (18.5)/94 (26.4)76 (18.5)/102 (28.7)67 (16.3)/98 (27.5)319 (77.6)/236 (66.3)
Men (referent)1.01.01.01.01.0
Women (OR 95% CI)1.8 (1.4–2.5)1.7 (1.2–2.4)1.9 (1.4–2.6)2.1 (1.5–2.9)0.9 (0.7–1.1)
Distal tumors
Men/women N (%)24 (6.2)/25 (7.9)18 (4.7)/16 (5.1)13 (3.4)/12 (3.8)11 (2.8)/13 (4.1)363 (93.8)/291 (92.1)
Men (referent)1.01.01.01.01.0
Women (OR 95% CI)1.4 (0.7–2.5)1.1 (0.5–2.2)1.2 (0.5–2.8)1.5 (0.7–3.6)1.0 (0.8–1.2)
  • a Number and percentage of cases with MSI+ and MSI− tumors for men and women.

  • b Adjusted for age, cigarette smoking, and alcohol consumption comparing risk MSI+ vs. control and MSI− vs. control. There are 1288 male controls and 1117 female controls.