Table 3

MSI as determined by the panel of 12 markers, reproduction, and hormone use

Reproductive factorsControls n (%)MSI+ n (%)MSI− n (%)P MSI+ vs. MSI−
Number of pregnancies
None93 (8.3)24 (16.4)41 (7.6)<0.01
1–2288 (25.7)26 (17.8)147 (27.1)
3+739 (66.0)96 (65.8)355 (65.4)
Oral contraceptive use (% ever for ≥3 months)280 (25.0)24 (16.4)133 (24.5)0.04
HRT
Ever for ≥3 months354 (36.1)46 (35.7)161 (33.1)0.58
Recent259 (73.5)23 (50.0)115 (71.4)<0.01
Former94 (26.5)23 (50.0)46 (28.6)<0.01
Mean (SD)Mean (SD)Mean (SD)
Age at first pregnancy (yr)23.6 (4.5)23.4 (4.1)23.8 (4.7)0.42
Age at last pregnancy (yr)31.8 (5.7)31.6 (5.6)31.5 (5.9)0.84
Total months pregnant31.2 (16.8)32.8 (16.5)29.6 (16.3)0.05
Age menarche (yr)12.9 (1.6)12.9 (1.4)13.1 (4.0)0.30
Total ovulatory months376.0 (93.7)391.0 (81.8)375.1 (94.0)0.05
Age at menopause47.4 (7.3)48.3 (6.9)47.3 (6.8)0.11