Table 1

In vitro evaluation of R115777 with isolated enzymes and intact cells

ParameterIC50 (nm with 95% confidence limits) or % inhibition at highest tested concentration
Isolated FPT
Lamin B CVIM peptide0.86 (0.61–1.2)
K-RasB CVIM peptide 7.9 (6.8–2.37)
Isolated GGPT I
Lamin B CVIL peptide40% at 50 μm
Substrate-dependent growth of transfected NIH 3T3 fibroblasts
Untransfected0% at 500 nm
T24 H-ras 1.7 (1.3–2.4)
v-raf97 (74–131)