Table 2

Summary of antiproliferative effects of R115777 in 53 human tumor cell lines grouped by ras gene status

Ras gene statusR115777-sensitive (IC50 <100 nm)R115777-resistant
Percent % (actual incidence)Percent % (actual incidence)
Ras mutation65% (13/20)35% (7/20)
(any ras gene)
ras wild type82% (27/33)18% (6/33)
N-ras or H-ras mutation100% (6/6)a0% (0/6)
K-ras mutation50% (7/14)b,c50% (7/14)
  • a N-ras plus H-ras mutants compared with ras wild type: sensitivity does not correlate with ras mutation byχ 2 test.

  • b K-ras mutants compared with ras wild type: sensitivity correlates with ras mutation status.

  • c K-ras mutants compared with N-ras plus H-ras mutants: sensitivity correlates with K-ras mutation status.