Table 3

Antiproliferative effects of R115777: representative data for different tumor tissue types

TumorCell lineSensitivity to R115777Ras gene status
IC50 (nm)Gene (codon)
PancreaticSU86.869.5K-ras (12)
CAPAN-216K-ras (12)
PANC-1>500K-ras (12)
AsPC-1>500K-ras (12)
CAPAN-1>500K-ras (12)
BladderT245.2H-ras (12)
RT42.7Wild type
563727Wild type
HT-11971.7H-ras (61)
J824.6Wild type
MelanomaC326.3Wild type
RPMI 7951111Wild type
SK-MEL-250N-ras (61)
SK-MEL-315Wild type
SK-MEL-56.8Wild type
SK-MEL-258.3Wild type
WM-1153.2Wild type
LungNCI-H460>500K-ras (61)
NCI-H2926.5Wild type
A549>500K-ras (12)
NCI H44136K-ras (12)
Rhabdomyo-sarcomaA6733.9Wild type
Rd9N-ras (61)
Hs769T44Wild type
A2044.8Wild type