Cytotoxicity in monolayer culture of normal peritoneum and ovarian cancer cells after expression to Ad-Lp-CD and Ad-CMV-CD vectors and 5FC (percentage of cells killed)
| In Ad-CMV-CD- and Ad-Lp-CD-infected samples, 500 μm 5-FC were added and incubated for 5 days, then the percentage of cells killed was estimated by comparing the percentage of cells which had died in the infected and uninfected control flasks. | ||
|---|---|---|
| Ad-CMV-CD | Ad-Lp-CD | |
| Ascites | 98% | 85% |
| Metastatic tumor | 85% | 70% |
| Primary tumor | 90% | 75% |
| Normal peritoneum | 95% | 10% |