Table 4

Cytotoxicity in monolayer culture of normal peritoneum and ovarian cancer cells after expression to Ad-Lp-CD and Ad-CMV-CD vectors and 5FC (percentage of cells killed)

In Ad-CMV-CD- and Ad-Lp-CD-infected samples, 500 μm 5-FC were added and incubated for 5 days, then the percentage of cells killed was estimated by comparing the percentage of cells which had died in the infected and uninfected control flasks.
Ad-CMV-CDAd-Lp-CD
Ascites98%85%
Metastatic tumor85%70%
Primary tumor90%75%
Normal peritoneum95%10%