Table 1

Altered gene expression during tumor progression

Decreased gene expressionIncreased gene expression
Fc receptor, IgGComplement component 3
Histocompatibility 2, class II, locus Mb1Gro 1/KC (DD)a
Major histocompatibility locus class II region/BING4Interleukin 12B
Myeloid differentiation primary response gene 116LMP7 (DD)
Receptor RDC1/chemokine orphan receptor 1Lymphocyte antigen 6 complex (DD)
TAPA-1/CD81Macrophage colony stimulating factor 1
IgK J region recom. signal binding protein
Signal transduction/Transcription
CalmodulinSignal transduction/Transcription
Dekc-Met (DD)
Eph receptor A2Chromatin nonhistone high mobility group protein/HGM-I(Y) (DD)
Fibroblast growth factor receptor 1MYC-associated zinc finger protein (purine-binding transcription factor)
MAP kinase phosphatase-1/ERPKinase MATK/Janus kinase 3
High mobility group protein 14Rap 1b (DD)
Immediate early response 3/IER3Receptor SAP1/Protein tyrosine phosphatase (non-receptor type 13)
Kinase HEK11Receptor TRK/Neurotrophic tyrosine kinase receptor type 3
Kinase sykTranscription factor E2a
Neurogenic differentiation 3Transcription factor E2F-5
Plexin2Yap65 (DD)
Protein kinase, IFN inducible dsRNA-dependent inhibitor
Protein tyrosine phosphatase, receptor type, KGrowth/Apoptosis/Repair
Trop2 geneCell cycle cdc25
Wingless-related MMTV integration site4C-IAP-1 (inhibitor of apoptosis-1)
Zinc finger protein, X-linkedCyclin D1
Growth/Apoptosis/RepairForkhead box G1
Apoptosis/death-associated protein1gas 5 (DD)
Bone morphogenetic protein 1gas6/growth arrest-specific 2
Caspase-14Homeo box D9
CalcyclinHomeo box D10
Cdk inhibitor 4 (P27)PEA-15
cdk inhibitor 1A (P21) Cyclin D2PDGF-α
DNA damage-inducible transcript 1Proliferating cell nuclear antigen
Fibroblast-inducible secreted proteinRepair DNApolB(Werner)/HMGP-I/C
Repair hepB assoc
Adhesion/MigrationReplication protein A 14 KD subunit
Adhesion junction plakoglobinSentrin (Nedd8, DD)
Adhesion SQM1Ubiquitin-activating enzyme E1
Cadherin 1
Collagen binding protein 1Adhesion/Migration
Disintegrin and metalloproteinase domain 12 (meltrin α)ADAMTS-1 (DD)
EpicanExtracellar proteinase inhibitor
FibronectinFibulin glycoprotein
Heparan/perlecan (heparan sulfate proteoglycan 2)Osteopontin
Laminin γ 2Metabolism
MucinCytochrome P450
Plasminogen activator inhibitor, type IIDodecenoyl-coenzymeAδ isomerase
Procollagen, type I, α 1glutathione-S-transferase (DD)
Procollagen, type IV, α 1Hemoglobin β, pseudogene bh3
Selectin/integrin β-7Histone deacetylase 5
Tetraspan TM4SF (Tspan-6)Methlmalonyl CoA mutase (DD)
Thrombospondin4Methylenetetrahydrofolate dehydrogenase
Thymosin β4 (DD)Mitochondrial outer membrane protein (OMP25)
Vascular cell adhesion molecule 1Ribosomal protein L18a (DD)
ThrombomodulinParaoxonase-3 (DD)
Selenium binding protein 1
MetabolismTransglutaminase 2, C polypeptide
Aldolase 1, A isoform
ASM-like phosphodiesterase 3aStructural and other proteins
ATPase, Ca++ transportingCapping protein (DD)
cGMP-phospdies/osteoblast specific factor 2Cytoskeletal caveolin
Creatine kinase, brainDynein light intermediate chain (DD)
Creatine kinase, muscleNeurofibromatosis 2
Lipoprotein lipaseSomatic histone binding protein NASP
Murine Glvr-1 mRNASperm protein Sp17 (DD)
Poly(A) polymeraseTestis-derived transcript
Selenoprotein P, plasma, 1
Secreted phosphoprotein 1
Stress diamine
Synthesis DNA polD/polymerase δ 2 regulatory subunit
Thioredoxin-related protein
Epican/gonadotropin-regulated testicular RNA helicase
Structural and other Proteins
Actinin α 3
Actin β cytoplasmic
Actin-binding protein (DD)
Cofilin 2
Formin-binding protein 21
Keratin complex 2, basic, gene 8
Modification tastin (DD)
Motor kinesin/kinesin heavy chain member 5B ubiquitous
Motor mitoti mitotic kinesin-like protein-1
Myosin light chain, alkali, fast skeletal muscle
Ryanodine receptor 1
Sid23p/actin depolymerizing factor homolog
Spectrin-domain protein (DD)
Tropomyosin a (DD)
Tubulin α 4
  • a Underline indicates genes detected by DD and confirmed by Northern blot.