Table 3

Correlation between clinical data and methylation of the different genes

Gene
RARĪ²TIMP-3p16INK4aMGMTDAPKECADp14ARFGSTPAny gene
A.% methylated
Sex
Female454213163236681
(n = 31)P = 0.018
Male3820302225169783
(n = 76)P = 0.048P = 0.005
Age (yrs)
<654629252116228686
(n = 63)
>653223252023119777
(n = 44)
Smoking
Noa3333011222202267
(n = 9)
Yesb4126282118179584
(n = 98)
TNM stagec
Stage I43212121212111282
(n = 61)
Stage II33292919191952495
(n = 21)(P = 0.005)
Stage III403632201284472
(n = 25)
Histology
AC49241327161611482
(n = 45)(P = 0.02)
SCC3523371921197781
(n = 43)
LCC2525252505000100
(n = 4)
ASC273636927189982
(n = 11)
Carc50500025002575
(n = 4)
B.Months survival (mean)
Overall survival534538474668443248
(all stages)(P = 0.005)
Stage I61563261497547NE57
(P = 0.03)
Stage II474044354239222734
Stage III342824191741NE1327
C.Pack-years smoked (mean)
Pack-years373949444247524043
  • a Never/nonsmokers

  • b Smokers (mean pack-years, 31).

  • c TNM, tumor-node-metastasis; AC, adenocarcinoma; SCC, squamous cell carcinoma; LCC, large cell carcinoma; ASC, adenosquamous carcinomas; Carc, carcinoid; NE, not evaluable because all observations are censored. Ps are given under the comparisons.