Table 5

Effect of increasing doses of ITs on toxicity and tumor response in mice

ITDeath/TotalaPRbCRb
M1(dsFv)-PE38
 0.075 mg/kg × 30/55/53/5
 0.15 mg/kg × 30/1010/108/10
 0.3 mg/kg × 30/1010/109/10
 0.45 mg/kg × 30/1010/109/10
 0.75 mg/kg × 33/107/7c7/7c
M16(dsFv)-PE38
 0.075 mg/kg × 30/55/54/5
 0.15 mg/kg × 30/1010/107/10
 0.3 mg/kg × 30/1010/109/10
 0.45 mg/kg × 30/1010/1010/10
 0.75 mg/kg × 30/1010/1010/10
SS1(dsFv)-PE38
 0.2 mg/kg × 30/1010/102/10
 0.4 mg/kg × 32/108/8c2/8c
 0.6 mg/kg × 33/52/2c0/2c
St6(dsFv)-PE38
 0.2 mg/kg × 30/1010/103/10
 0.4 mg/kg × 30/1010/103/10
 0.6 mg/kg × 30/1010/106/10
B3(dsFv)-PE38
 0.05 mg/kg × 30/55/50/5
 0.1 mg/kg × 30/55/50/5
 0.15 mg/kg × 30/55/51/5
 0.2 mg/kg × 30/55/55/5
Mt9(dsFv)-PE38
 0.05 mg/kg × 30/55/50/5
 0.1 mg/kg × 30/55/50/5
 0.15 mg/kg × 30/55/51/5
 0.2 mg/kg × 30/55/55/5
PBS/0.2% HSAd × 30/500/500/50
  • a Number of mice that died divided by number injected.

  • b PR, reduction of the sum of the tumor length and width by >50% of pretreatment values. CR, no tumor for a minimum of 4 days.

  • c Dead mice could not be evaluated.

  • d HSA, human serum albumin.