Table 3

Multivariate analysis in 78 patients with abundant intratumoral CD8+ cells

A.Kaplan-MeierMultivariate analysis/Cox proportional hazards model
Log-rank test; PParameter estimateSEPHazard ratio95% C.I.aP
Stage<0.00010.90.240.00012.51.5–3.80.0001
CD8/Ki-67b0.0003−0.990.420.02c0.30.15–0.780.01
Ki-67 (cancer)d<0.00010.770.580.182.50.86–7.40.09
Grade0.00060.540.440.22
Histologye0.004−0.20.470.62
B.Kaplan-MeierMultivariate analysis/logistic model
Log-rank test; PParameter estimateSEPOdds ratio95% C.I.aP
Stage<0.00011.60.430.00034.82.0–11.30.0003
CD8/Ki-67b0.0003−310.0030c0.050.007–0.340.002
Ki-67 (cancer)d<0.000120.970.046.41.3–320.02
Grade0.0006−0.130.980.87
Histologye0.004−0.0410.97
  • a C.I., confidence interval.

  • b Labeling index of intratumoral CD8+ cells for Ki-67 categorized into 0 (<9.0% = median value) and 1 (>9.1%).

  • c Arrow, step-down parameter selection.

  • d Categorized into 0 (<1.5% = median value) and 1 (>1.5%).

  • e Categorized into clear cell type and others.