Relative changes in subcutaneous tumor volumes during the course of vehicle and TNP-470 treatment
Treatmenta | Tumor type | |
---|---|---|
V− | V+ | |
Vehicle control | 46.9 ± 76%b | 128 ± 79% |
TNP-470 30 mg/kg | −15 ± 28% | 44 ± 32% |
TNP-470 60 mg/kg | −19 ± 20% | −20 ± 30% |
a All treatments consisted of five doses administered every 48 h.
b All values are mean ± SD, with n = 4 except the TNP-470 60 mg/kg group, in which n = 3. The relative change in tumor volume during the treatment courses was calculated as: 100 × (tumor volume following the last dose of TNP-470 or control − tumor volume prior to the first dose of TNP-470 or control)/(tumor volume prior to the first dose of TNP-470 or control).