Table 1

Relative changes in subcutaneous tumor volumes during the course of vehicle and TNP-470 treatment

TreatmentaTumor type
V−V+
Vehicle control46.9 ± 76%b128 ± 79%
TNP-470 30 mg/kg−15 ± 28%44 ± 32%
TNP-470 60 mg/kg−19 ± 20%−20 ± 30%
  • a All treatments consisted of five doses administered every 48 h.

  • b All values are mean ± SD, with n = 4 except the TNP-470 60 mg/kg group, in which n = 3. The relative change in tumor volume during the treatment courses was calculated as: 100 × (tumor volume following the last dose of TNP-470 or control − tumor volume prior to the first dose of TNP-470 or control)/(tumor volume prior to the first dose of TNP-470 or control).