Table 3

Physiological and TMZ pharmacokinetic parameters from the subcutaneous tumor microdialysis study

ParameteraTreatment group
V− ControlV− TNP-470V+ ControlV+ TNP-470
Tumor Size (mm3)1220 ± 760b910 ± 6272286 ± 11601081 ± 506
Body weight (g)335 ± 40315 ± 56309 ± 35271 ± 52
ss Cp (μg/ml)c25.6 ± 4.527.7 ± 7.222.5 ± 1.523.9 ± 7.2
ss Ctif (μg/ml)12.3 ± 2.912.9 ± 2.716.6 ± 4.312.0 ± 1.8
ss Ctif/Cp0.49 ± 0.110.49 ± 0.170.73 ± 0.15d0.52 ± 0.09
  • a ss Cp, steady-state TMZ plasma concentration; ss Ctif, steady-state tumor interstitial fluid TMZ concentrations. Body weights and tumor volumes are reported from the last day of vehicle or TNP-470.

  • b Values reported as mean ± SD; n = five or six animals/group.

  • c ss Cp values are averaged over time and animals. Each animal had ∼12 timed samples.

  • d Significantly different than V+ TNP-470 group; P < 0.05.