Table 1

The genes with altered expression in chemoresistant cell lines compared with the sensitive parent cell lines (resistant/sensitive ratio)

Genes with a ratio >1.5 or <0.5 are shown in bold. The numbers in the table represent the gene expression ratio between chemoresistant and chemosensitive cell lines. 1.5 and 0.5 are set as threshold of over- and underexpression, respectively.
GeneW1L2-TDXRKO-TDXMCF-TDXH630-TDXH630-5FU
Thymidylate synthase 3.61 3.54 5.80 1.45 2.53
YES1 proto-oncogene 0.41 3.27 3.23 1.82 2.49
T-cell protein-tyrosine phosphatase 0.53 4.19 3.84 1.211.15
Activator 1 40-kDa subunit 0.881.22 2.10 NEa0.75
CAK1 antigenNE0.79 1.53 0.78 8.53
RPD3 protein0.560.861.38NE 2.01
Checkpoint suppressor 1 1.100.891.241.07 0.35
α1 catenin0.971.061.22NE 3.18
TGF-β3 0.790.841.11NE 2.03
Semaphorin III 0.880.791.09NE 2.82
Ephrin type-B receptor 2 precursor 1.031.441.090.93 2.28
Lymphotoxin β receptor precursor0.610.661.08NE 2.02
c-rel proto-oncogene protein0.951.211.021.36 0.36
Stem cell factor precursor NENE0.991.08 5.28
Interleukin-4 precursor NE1.220.950.68 2.33
Interferon-inducible protein 9–27 0.890.890.921.23 0.26
CD91 antigen1.120.940.91NE 0.46
Fibroblast growth factor receptor 1 precursor 1.091.210.670.88 6.18
p68-trk-T3 oncoproteinNENE0.631.32 0.11
Procollagen 3 α1 subunit precursor 1.61 0.730.620.97 4.52
Integrin α91.400.810.591.13 2.32
β NGF 1.31 1.55 0.590.99 0.38
Retinoic acid receptor α1 NE 2.92 0.40 1.420.69
PRSM1 metallopeptidase 0.721.12 0.40 NE1.18
Mitotic feedback control protein MADP2 homologue 0.971.14 0.40 NE0.88
c-myc oncogene1.261.20 0.29 1.320.89
Metalloproteinase inhibitor 3 precursor 1.261.28NENE 2.30
DNA topoisomerase IIβ 0.88NENE0.97 0.46
  • a NE, not evaluable.