Table 5

Postinitiation effects of dietary administration of LBR on NMBA-induced esophageal tumorigenesis in the F344 rat

GroupNMBA 0.25 mg/kgDiet administeredRats (n)Tumor incidence %Tumor multiplicity mean (± SE)Tumor size mm3 mean (± SE)
Week 15 of study
 1AIN-76A8000
 210% LBRs8000
 3+AIN-76A850.00.75 (0.31)0.34 (0.16)
 4+5% LBRs825.00.38 (0.26)0.12 (0.08)
 5+10% LBRs812.50.13 0.13)0.04
Week 25 of study
 1AIN-76A10000
 210% LBRs10000
 3+AIN-76A1586.61.40 (0.25)1.2 (0.71)
 4+5% LBRs1540.0a0.53b (0.19)0.29 (0.15)
 5+10% LBRs1546.7a0.80b (0.30)0.54 (0.21)
Week 35 of study
 1AIN-76A10000
 210% LBRs10000
 3+AIN-76A1492.92.00 (0.31)3.91 (1.57)
 4+5% LBRs1453.3a0.67b (0.19)3.60 (2.74)
 5+10% LBRs1580.01.53 (0.32)1.01 (0.66)
  • a Significantly lower than Group 3 as determined by χ2 test (P< 0.05).

  • b Significantly lower than Group 3 as determined by analysis of variance (P < 0.05).