Table 6

Effects of dietary administration of LBRs on PCNA LIs in the F344 rat esophagus

GroupNMBA 0.25 mg/kgDiet% positive PCNA LI (± SE)% inhibitiona
Week 15 of study
 1AIN-76A18.5 (0.8)
 210% LBRs18.3 (1.7)
 3+AIN-76A31.5 (1.3)
 4+5% LBRs22.4 (1.4)b29
 5+10% LBRs22.6 (0.7)b28
Week 25 of study
 1AIN-76A21.3 (1.2)
 210% LBRs20.0 (1.2)
 3+AIN-76A32.2 (1.8)
 4+5% LBRs22.7 (0.9)b30
 5+10% LBRs25.7 (0.9)b20
Week 35 of study
 1AIN-76A20.7 (0.9)
 210% LBRs20.8 (1.6)
 3+AIN-76A36.0 (1.4)
 4+5% LBRs22.3 (1.1)b38
 5+10% LBRs34.3 (1.5)5
  • a The percentage inhibition in berry-treated groups is relative to NMBA controls (Group 3).

  • b Statistically significant relative to NMBA controls (Group 3) (P < 0.05).