Table 2

Spectrum of spontaneous tumors in p21-null mice

Type of tumorNo. of tumorsRelative incidence (%)
In females (n = 28a)In males (n = 37b)Total (n = 65)
Histiocytic sarcomas18163452.3%
Hemangiomas/h-sarcomasc681421.5%
B-cell lymphomas36913.9%
Lung carcinomas0334.6%
Skin tumorsd0223.1%
Testis tumorse0223.1%
Urinary bladder tumorf0111.5%
  • a Of a total population of 93 female mice, 25 developed tumors (27%; see Table 1 <$REFLINK> ), including 3 that developed two independent tumors, yielding a total of 28 tumors.

  • b Of a total population of 58 male mice, 32 developed tumors (55%; see Table 1 <$REFLINK> ), including 5 that developed two independent tumors, yielding a total of 37 tumors.

  • c Eleven benign hemangiomas and three malignant hemangiosarcomas.

  • d One benign keratoachantoma (Fig. 2E) <$REFLINK> and one sebaceous gland adenoma.

  • e One Leydig cell adenoma and one malignant Leydig cell tumor with lung metastatic nodules (Fig. 2F) <$REFLINK> .

  • f Further characterization was not possible because of autolysis.