Table 3

Spectrum of γ-radiation-induced tumors in p21-null mice

Mortality (9 months after irradiation)Irradiated wild type (n = 16a)Irradiated p21-null (n = 22b)
Dead with tumors13 (81%)c 7 (32%)
 7 T-cell lymphomasd 5 T-cell lymphomasd
 3 hemangiomas/h-sarc 1 hemangioma/h-sarc
 2 ovarian tumors 1 pituitary carcinoma
 1 fibrosarcoma
 1 rhabdomyosarcoma
 1 lung carcinoma
Cause of death unknown 3 (19%) 0 (0%)
Alive after 10 months 0 (0%)15 (68%)
  • a 6 females and 10 males.

  • b 18 females and 4 males.

  • c Two mice had two independent tumors.

  • d Thymic or multicentric.