Table 1

Body and organ weights and nose-tail length of treated and control rats after follow-up of 74 days

TreatmentSaline controlAmifostine 200 mg/kgDoxorubicin 3 mg/kgAmifostine (50 mg/kg) + Doxorubicin (3 mg/kg)
WeightWeight index (mg/g)aWeightWeight index (mg/g)aWeightWeight index (mg/g)aWeightWeight index (mg/g)a
Body weight (g)a455 ± 9400 ± 16283 ± 36295 ± 19
Kidney weight (mg)a1,618 ± 283.6 ± 0.11,456 ± 553.6 ± 0.11,115 ± 122b4.0 ± 0.21,120 ± 80b3.8 ± 0.2
Spleen weight (mg)a913 ± 272.0 ± 0.1890 ± 262.2 ± 0.1539 ± 118b1.8 ± 0.2798 ± 1472.9 ± 0.7
Liver weight (mg)a17,312 ± 82338.0 ± 1.415,100 ± 67737.7 ± 0.811,697 ± 1552b41.8 ± 2.610,591 ± 987b35.7 ± 1.8
Heart weight (mg)a1,653 ± 383.6 ± 0.11,477 ± 553.7 ± 0.11,254 ± 151b4.5 ± 0.2b1,441 ± 1204.9 ± 0.4b,c
Testis weight (mg)a1,560 ± 543.5 ± 0.11,535 ± 283.9 ± 0.1352 ± 95b1.2 ± 0.2b,c488 ± 119b,c1.7 ± 0.4c
Epididymis weight (mg)a533 ± 241.1 ± 0.1518 ± 171.3 ± 0.0106 ± 32b0.3 ± 0.0b,c157 ± 29b,c0.6 ± 0.1c
Seminal vesicle weight (mg)a536 ± 211.2 ± 0.1487 ± 161.2 ± 0.088 ± 31b,c0.3 ± 0.1b,c70 ± 17b,c0.2 ± 0.0b,c
Nose-tail length (mm)aLengthLength index (mm/g)LengthLength index (mm/g)LengthLength index (mm/g)LengthLength index (mm/g)
474 ± 21.1 ± 0.0468 ± 41.2 ± 0.1423 ± 11b,c1.6 ± 0.2b430 ± 8b1.5 ± 0.1b
  • a Values are given as mean ± SE.

  • b P < 0.05 compared with value in control group.

  • c P < 0.05 compared with value in amifostine 200 mg/kg-treated group.