Table 3

Vascularization analysis of tumors obtained by injecting SkBr3 or SkBr3/HOXB7 cells into athymic nude mice

Tumors from three independent experiments were analyzed at day 7. The entire tumor-growing area was evaluated with the help of a mm2 grid. Vascularization is expressed as number of capillaries/field at 400× enlargement and reported as mean ± SD.

Anti-CD34Anti-CD31
SkBr3SkBr3/HOXB7aSkBr3SkBr3/HOXB7a
3.0 ± 0.613.5 ± 3.52.7 ± 1.613.0 ± 2.0
5.0 ± 2.014.6 ± 2.74.0 ± 1.014.0 ± 2.0
7.0 ± 3.019.0 ± 6.36.0 ± 3.016.0 ± 4.0
4.0 ± 2.015.0 ± 2.54.0 ± 2.016.0 ± 2.0
  • a P < 0.0002.