Table 3

Hot spots in TP53 of PAH adducts and mutations associated with exposure to cigarette smoke or smoky coal emissions

ExonCodonHot spotsa
PAH adductsCigarette mutationsSmoky coal mutations
5154++
156+
157++
158++
159+
7237+
245++
248++
249++
8273+++
  • a References for PAH adducts and cigarette smoke mutations are 17 and 4 , respectively. The smoky coal mutation spectrum had four codons with one mutation, four codons with two mutations, and three codons with three mutations. We identified hot spots as those three codons that each contained three mutations.