Table 1

Amino acid variations in MXR/BCRP/ABCP and corresponding transport phenotype

Efflux of rhodamine 123 (Rhod) and mitoxantrone (Mitox) assayed by flow cytometry.
Cell lineAmino acid 482RhodMitox
S1-M1-80G++++++
MCF AdVp3000T++++++
MCF-7/MXR+++
MCF MX100R+++
MCF FLV1000R+++
MCF MX8R++
A549 MX10R++
H460 MX10R++
SF295 MX10R++
MCF-7R+
S1R