Table 2

Lysis of human tumor cell lines by MUC1-specific CTL

Tumor cell linesaHLA-A2 expressionMUC1 expressionCTL.M1.1 Percentage of specific lysis at E:TCTL.M1.2 Percentage of specific lysis at E:T
310.3310.3
A-498++28221422144
U266++1915716263
SK-OV-3+−12−2−2−3−2
IM-9+−15−4−2−14−13−12
  • a The cytotoxic activity of CTL.M1.1 and CTL.M1.2 against human tumor cell lines was analyzed in a standard 51Cr-labeled release assay. The HLA-A2 and MUC1 expression was analyzed using specific monoclonal antibodies. Data are presented from one representative experiment.