Table 1

Summary of treatment schedules for huAb A33 in patients with colon cancer

Protocol and patient no.huAb A33 dose mg Ig/m2Treatment schedule
MSKCC-94-100A
 COL-1 -510Cycles (4 weeks, 1× antibody infusion per week, followed by 1 week off)
 COL-6 -825Cycles (4 weeks, 1× antibody infusion per week, followed by 1 week off)
 COL-9 -1150Cycles (4 weeks, 1× antibody infusion per week, followed by 1 week off)
MSKCC-96-22
 COL-12 -281010 weeks, 1× antibody infusion per week
MSKCC-98-056
 COL-29, 37, 39514 weeks, 1× antibody infusion per week, BOF-Strep,a week 5–14, once per week
 COL-30, 33, 35, 381014 weeks, 1× antibody infusion per week, BOF-Strep,a week 5–14, once per week
 COL-31, 32, 34, 362514 weeks, 1× antibody infusion per week, BOF-Strep,a week 5–14, once per week
 COL-40, 414014 weeks, 1× antibody infusion per week, BOF-Strep,a week 5–14, once per week
MSKCC-98-011
 COL-42 -4410131I-labeled huAb A33, 1× dose per week
  • a 1,3-bis(2-chloroethyl)-1-nitrosourea, Oncorin, fluorouracil, and streptozotocin.