Table 4

Transcripts most repressed in adenomas and cancersa

Tag sequenceNormalAdenomaCancerUniGene IDTranscript name
NC-1NC2AD-A1AD-BTu-981Tu-102
GTCATCACCA3522000032966Guanylate cyclase activator 2B
CCTTCAAATC2917001023118Carbonic anhydrase I
TCTGAATTAT2416001050964Carcinoembryonic antigen-related cell adhesion molecule 1
TTATGGTGTG11170000271499ESTsb
CTGGCAAAGG1422100072789Hypothetical protein FLJ20217
AGGTGACTGG10140000No match
CTTATGGTCC36110110179608Retinol dehydrogenase homologue
ATGATGGCAC1232101084072Transmembrane 4 superfamily member 3
GTCCGAGTGC17300003337Transmembrane 4 superfamily member 1
ATTTCAAGAT 35 21 0 2 1 0 155097 Carbonic anhydrase II (CA2)
CAAGAGTTTC1420000183617ESTs
GCCATCCTCC9130100No match
ACCCAACTGC1230000232604Homo sapiens cDNA: FLJ22675 fis, clone HSI10553
GCCCACGTCA780000No match
TTTGGTTTCA2130000No match
CTCAGAACTT1831000194710N-Acetylglucosaminyl transferase 3, mucin type
CCAACACCAG9191001181165Eukaryotic translation elongation factor 1 α 1
GCCACATACT3900004984KIAA0828 protein
GTATTGGGGC570000No match
CCGGCTTGAG7400002722Inositol 1,4,5-trisphosphate 3-kinase A
GATATGTAAA1100000227059Chloride channel, calcium-activated, family member 4
CATAGGTTTA 66 39 4 1 5 0 1650 Solute carrier family 26, member 3 (DRA)
GTCCTGAACA73000078546ATPase, Ca2+ transporting, plasma membrane 1
  • a These tags displayed at least 20-fold decrease in both neoplastic states. The numbers given are the raw tag counts for each tag observed in each library. Transcript name provides a description of matching UniGene cluster (Build 3/13/01). Rows shown in bold are genes that were tested and confirmed by quantitative PCR to be differentially expressed.

  • b ESTs, expressed sequence tags.