Table 4

Stratified analysis of MMP-1 genotypes by gender and smoking status

MMP-1 genotypesCasesControlsUnadjusted OR [95% CI]Adjusted OR [95% CI]
Overall
 Male 1G/1G, 1G/2G 129172ReferenceReference
2G/2G 120762.11 [1.45–3.06]2.15 [1.42–3.26]a
 Female 1G/1G, 1G/2G 117135ReferenceReference
2G/2G 90681.53 [1.02–2.29]1.34 [0.84–2.15]a
0–24 pack-years
 Male 1G/1G, 1G/2G 1826ReferenceReference
2G/2G 14121.69 [0.64–4.43]1.75 [0.65–4.74]b
 Female 1G/1G, 1G/2G 2226ReferenceReference
2G/2G 13121.28 [0.49–3.33]1.23 [0.45–3.33]b
24.1–40 pack-years
 Male 1G/1G, 1G/2G 2137ReferenceReference
2G/2G 21162.31 [1.00–5.33]2.80 [1.14–6.87]b
 Female 1G/1G, 1G/2G 2530ReferenceReference
2G/2G 19191.20 [0.53–2.73]1.31 [0.55–3.11]b
41–61.5 pack-years
 Male 1G/1G, 1G/2G 3945ReferenceReference
2G/2G 34201.96 [0.98–3.93]1.99 [0.99–4.02]b
 Female 1G/1G, 1G/2G 3232ReferenceReference
2G/2G 24131.85 [0.81–4.21]1.83 [0.80–4.23]b
≥ 61.5 pack-years
 Male 1G/1G, 1G/2G 4358ReferenceReference
2G/2G 47262.43 [1.31–4.52]2.44 [1.31–4.54]b
 Female 1G/1G, 1G/2G 2027ReferenceReference
2G/2G 18112.21 [0.87–5.63]2.21 [0.86–5.69]b
  • a Adjusted by age and smoking status.

  • b Adjusted by age.