Table 1

β-Catenin expression in dysplastic ACF, adenomas, and carcinomas

Membranous expression of β-catenin is shown as the product of the intensity and percentage of colonic epithelial cells with immunohistochemically demonstrable β-catenin in membranes; cytoplasmic and nuclear expressions are scored on the basis of the percentage of colonic epithelial cells with those phenotypes (see “Materials and Methods”).
MembranousaCytoplasmicbNuclearc
Total N (%)9–12d (%)5–8 (%)0–4 (%)d (%)1+ (%)2+ (%)3+ (%)d (%)1+ (%)2+ (%)
Dysplastic ACF46 (100)87112462622687130
Adenoma12 (100)4250817253325422533
Carcinoma10 (100)40501020301040503020
  • a Membranous expression of β-catenin decreases as lesions proceed from dysplastic ACF to adenomas to carcinomas (P = 0.0007, Poisson log-linear model).

  • b Cytoplasmic expression of β-catenin increases as lesions proceed from dysplastic ACF to adenomas to carcinomas (P = 0.0050, Poisson log-linear model).

  • c Nuclear expression of β-catenin increases as lesions proceed from dysplastic ACF to adenomas to carcinomas (P = 0.0001, Poisson log-linear model).

  • d β-Catenin shows strong membranous expression and lacks cytoplasmic and nuclear expression in normal colonic epithelial cells.