Membranous expression of β-catenin is shown as the product of the intensity and percentage of colonic epithelial cells with immunohistochemically demonstrable β-catenin in membranes; cytoplasmic and nuclear expressions are scored on the basis of the percentage of colonic epithelial cells with those phenotypes (see “Materials and Methods”). | |||||||||||
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Membranous^{a} | Cytoplasmic^{b} | Nuclear^{c} | |||||||||
Total N (%) | 9–12^{d} (%) | 5–8 (%) | 0–4 (%) | −^{d} (%) | 1+ (%) | 2+ (%) | 3+ (%) | −^{d} (%) | 1+ (%) | 2+ (%) | |
Dysplastic ACF | 46 (100) | 87 | 11 | 2 | 46 | 26 | 22 | 6 | 87 | 13 | 0 |
Adenoma | 12 (100) | 42 | 50 | 8 | 17 | 25 | 33 | 25 | 42 | 25 | 33 |
Carcinoma | 10 (100) | 40 | 50 | 10 | 20 | 30 | 10 | 40 | 50 | 30 | 20 |
a Membranous expression of β-catenin decreases as lesions proceed from dysplastic ACF to adenomas to carcinomas (P = 0.0007, Poisson log-linear model).
b Cytoplasmic expression of β-catenin increases as lesions proceed from dysplastic ACF to adenomas to carcinomas (P = 0.0050, Poisson log-linear model).
c Nuclear expression of β-catenin increases as lesions proceed from dysplastic ACF to adenomas to carcinomas (P = 0.0001, Poisson log-linear model).
d β-Catenin shows strong membranous expression and lacks cytoplasmic and nuclear expression in normal colonic epithelial cells.