Table 2

β-Catenin expression in colorectal ACF

Membranous expression of β-catenin is shown as the product of the intensity and percentage of colonic epithelial cells with immunohistochemically demonstrable β-catenin in membranes; cytoplasmic and nuclear expressions are scored on the basis of the percentage of colonic epithelial cells with those phenotypes (see “Materials and Methods”).
MembranousaCytoplasmicbNuclearc
Total ACF N (%)9–12d (%)5–8 (%)0–4 (%)d (%)1+ (%)2+ (%)3+ (%)d (%)1+ (%)2+ (%)
Atypia48 (100)100009640010000
Dysplasia46 (100)87112462622687130
 Mild34 (100)97305926969460
 Moderate7 (100)861401429431471290
 Severe5 (100)20602002080060400
  • a Membranous expression of β-catenin in ACF decreases as lesions proceed from mild to moderate to severe dysplasia (P = 0.0003, Poisson log-linear model).

  • b Cytoplasmic expression of β-catenin in ACF increases as lesions proceed from mild to moderate to severe dysplasia (P = 0.0016, Poisson log-linear model).

  • c Nuclear expression of β-catenin in ACF increases as lesions proceed from mild to moderate to severe dysplasia (P = 0.0266, Poisson log-linear model).

  • d β-Catenin shows strong membranous expression and lacks cytoplasmic and nuclear expression in normal colonic epithelial cells.