Table 1

Immunohistochemistry LI for PCNA and Ki-67 and foci of VEGF-positive cells as related to gender, treatment, and tumor volume in KS-transplanted (CD-1)BR nude mice

GenderTreatmentAnimal codeTumor volume (cm3)LI (%)Foci of VEGF-positive cells/microscopic field
PCNAKi-67
MaleControl12.841.722.63.3
23.445.824.52.7
31.740.421.03.9
 Mean ± SD2.6 ± 0.942.6 ± 2.822.7 ± 1.83.3 ± 0.6
MaleNAC71.828.411.02.5
80.729.313.51.0
90.315.98.50.8
 Mean ± SD0.9 ± 0.824.5 ± 7.5a11.0 ± 2.5a1.4 ± 0.9b
FemaleControl131.437.420.92.9
140.923.214.51.6
150.631.516.52.3
 Mean ± SD1.0 ± 0.430.0 ± 7.117.3 ± 3.32.3 ± 0.7
FemaleNAC190.319.210.40.9
200.320.412.11.2
210.216.57.71.0
 Mean ± SD0.3 ± 0.1b18.7 ± 2.0b10.1 ± 2.2b1.0 ± 0.2b
  • a P < 0.01, compared with control.

  • b P < 0.05, compared with control.