Table 2

The expressiona of the DNA-PK proteins in normal human colon, adenoma, carcinoma, and normal tissue distant from cancera

Ku70Ku86DNA-PKcs
A) Normal (n = 23)176.62 ± 18.56113.10 ± 10.22129.90 ± 17.99b
B) Adenoma (n = 7)36.62 ± 11.0941.66 ± 14.7179.36 ± 20.47
C) Cancer (n = 11)85.68 ± 15.7663.57 ± 15.9778.91 ± 13.79
D) Normal from cancer (n = 11)189.06 ± 27.3196.55 ± 25.64133.79 ± 21.94
  • a Expression score (mean ± SE). The expression score, described in “Patients and Methods,” is the product of the intensity of expression multiplied by the percentage of cells expressing a given protein, and assesses numerically the expression of each protein. Statistically significant differences: Ku70: A versus B, P < 0.001; A versus C, P < 0.01; B versus D, P < 0.001; C versus D, P < 0.01. Ku86: A versus B, P < 0.01; A versus C, P < 0.05.

  • b n = 22.