Table 1

FAK heterozygous mice show no difference in malignant conversion frequency

Mice from both fak +/− and fak +/+ groups were subjected to chemical carcinogenesis, and total papilloma and carcinoma numbers were recorded. Carcinoma numbers were scored by morphological appearance on collection followed by histological confirmation after H&E staining of paraffin.
Mouse lineNo. of miceFirst carcinoma appearance (weeks)No. of carcinomas per no. of papillomasMalignant conversion frequency
fak +/+201813/3493.70%
fak +/−202210/2104.80%