Table 1

Antiproliferative activity of the indolocarbazoles (NB-506 and J-109,382) and CPT measured as IC50 ± SD by MTT assay

CPT (μm)RRaNB-506 (μm)RRJ-109,382 (μm)RR
CEM0.01 ± 0.010.11 ± 0.040.027 ± 0.029
CEM/C25.4 ± 2.95400.61 ± 0.1760.13 ± 0.105
DC3F0.07 ± 0.010.20 ± 0.020.023 ± 0.004
DC3F/C105.9 ± 1.8840.71 ± 0.5740.097 ± 0.0474
DU-1450.06 ± 0.060.23 ± 0.060.16 ± 0.11
DU-145/RC121.7 ± 7.63611.97 ± 0.8591.75 ± 1.311
P3880.05 ± 0.010.16 ± 0.040.017 ± 0.005
P388/CPT45>100>20000.3 ± 0.120.11 ± 0.106
  • a RR, resistance ratio, calculated as the ratio of the IC50 in the CPT-resistant cells relative to the parental cell line.