Table 2

The frequency and size of gastrointestinal tumors in Apc+/−, p21+/+, +/−, or −/− mice fed AIN-76A diet or Western-style diet

All mice Apc andNumber of tumors per mouseaVolume (mm3)a
AIN-76A dietWestern dietAIN-76A dietWestern diet
p21 1.7 ± 1.94.3 ± 1.9d9.6 ± 8.917.5 ± 13.0e
p21 2.1 ± 1.56.6 ± 3.9b,d12.1 ± 10.723.0 ± 15.2b,d
p21 3.7 ± 1.4c7.5 ± 4.9b,f16.7 ± 13.3c27.3 ± 20.2c,d
  • a Values are means ± SD.

  • b P < 0.05,

  • c P < 0.01, in comparison to the Apc+/−, p21+/+ mice (by Student’s t test).

  • d P < 0.001,

  • e P < 0.01,

  • f P < 0.05, in comparison to mice fed AIN-76A diet (by Student’s t test).