Table 1

Distribution of p53 codon 72 polymorphisms in Swedish and Italian women with HPV 16-positive cervical neoplasia and healthy controls

PPa (%)AP (%)AA (%)OR (95% CI)b
Swedish women
Controls16 /188 (9.0)83 /188 (44.0)89 /188 (47.0)1.0 (reference)
LCIN1 /30 (3.3)14 /30 (46.7)15 /30 (50.0)1.1 (0.5–2.4)
HCIN7 /64 (10.9)24 /64 (37.5)33 /64 (51.6)1.2 (0.7–2.1)
ICC4 /72 (5.6)22 /72 (30.6)46 /72 (63.9)2.0 (1.1–3.4)c
Italian women
Controls1 /40 (2.5)18 /40 (45.0)21 /40 (52.5)1.0 (reference)
LCIN2 /11 (18.0)3 /11 (27.3)6 /11 (54.5)1.1 (0.3–4.1)
HCIN1 /26 (3.8)12 /26 (46.2)13 /26 (50.0)0.9 (0.3–2.4)
ICC3 /43 (7.0)7 /43 (16.3)33 /43 (76.7)3.0 (1.1–7.6)c
  • a PP/AA, proline/arginine homozygotes; AP, heterozygotes.

  • b ORs for each diagnostic category in relation to the healthy controls are given with confidence intervals (CI) in parentheses.

  • c For both groups, P = 0.02 was obtained by Fisher’s exact test when comparing controls with cases of ICC.