Table 3

Combined effect of CYP17 and HSD17B1 high-risk alleles on riska of advanced breast cancer among women weighing 170 lbs. or less

No. of high-risk allelesbP (trend)
01234
Subjects weighing ≤170 lbs.
Controls (n = 1116)10931940624735
Advanced cases (n = 178)1344644413
RRc1.001.171.291.483.05
95% CI(0.61–2.26)(0.68–2.43)(0.76–2.86)(1.29–7.25)0.02
  • a Age, weight, and ethnicity adjusted.

  • b High risk alleles: CYP17, A2; HSD17B1, A.

  • c Relative risk for advanced breast cancer.