Table 4

Relative risks for advanced breast cancer by number of CYP17 and HSD17B1 high-risk alleles by ethnicitya

Sample size and no. of high-risk allelesAfrican- AmericanLatinaWhiteJapanese
Controls (n = 1508)459485277287
Stage 1 cases (n = 615)135138170172
Stage 2 cases (n = 235)68516452
0b1.00 (4)c1.00 (2)1.00 (2)1.00 (7)
11.49 (19)3.14 (20)1.95 (13)0.53 (10)
21.85 (27)2.00 (16)2.95 (29)0.55 (15)
31.98 (15)1.91 (10)3.60 (16)1.02 (17)
42.42 (3)3.38 (3)3.29 (4)1.70 (3)
  • a Age and weight adjusted.

  • b High risk alleles: CYP17, A2; HSD17B1, A.

  • c Number of advanced stage cases by number of high-risk alleles.