Table 4

Association of EGFR with survival in patients <55 years (n = 46) based on p53 gene status

Cases were screened for p53 gene status, and median survival (weeks after initial surgery) was determined for each of the four groups of cases based on gene status (left). A Cox multivariate analysis was performed to assess correlations of EGFR status with survival in p53 wild-type (p53wt) and p53 mutant (p53mut) subgroups. Adjustments for age, KPS, extent of resection, and protocol status resulted in similar findings (see text). HRs, 95% CIs, and Ps are as indicated on the right.

Median survival (no. of cases)Cox analysis (EGFR+ vs. EGFR−)
EGFR−EGFR+HR95% CIP
p53wt80 (22)46 (10)3.41.5–8.0<0.01
p53mut61 (12)148 (2)0.40.1–1.90.27