Table 1

The number of blood vessels in LLC-PlGF- and LLC-VEGF-induced tumor tissues derived from flt-1 TK (+/+) and flt-1 TK (−/−) micea

50–100 μm100–150 μm150–200 μm200–300 μm
LLC-PlGF
8-day flt-1 TK (+/+)40 ± 25b000
8-day flt-1 TK (−/−)20 ± 12000
16-day flt-1 TK (+/+)16.5 ± 7.13 ± 30.8 ± 1.40
16-day flt-1 TK (−/−)5.6 ± 3.70.3 ± 0.500
LLC-VEGF
16-day flt-1 TK (+/+)15 ± 2.31 ± 1.400
16-day flt-1 TK (−/−)13 ± 1.71 ± 0.800
  • a Average numbers of three sagittal sections of three tumor tissues were counted. The diameters of blood vessels are shown at 8 and 16 days (numbers/cm2) after intradermal implantation.

  • b Mean ± SD.