Table 2

Genes that showed differential expression level in OCUM-2MD3 and OCUM-2MLN compared to OCUM-2M

GenBank accession number, fold change verified by high-density oligonucleotide array and Northern blot, and one representative function of the genes as previously reported are described. Only the genes that showed expression change greater than 4-fold by oligonucleotide array and greater than 2-fold by Northern blot are listed, and genes are sorted by Northern blot data.

No.GenBankNorthern blotGeneChipGeneFunction
OCUM-2MD3
1K0139619.46.1α-1-antitrypsinProtease inhibitor
2X5200316.98.3Trefoil factor 1Growth factor
3L080448.17.7Trefoil factor 3Growth factor
4U598787.46.7rab32Unknown
5X730795.68.1Polymeric-immunogloblin receptorImmunity
6AB0067815.514.6Galectin 4Adhesion
7D498243.512.2MHC class I, BImmunity
8M948803.54.6MHC class I, AImmunity
9U330532.54.6Protein kinase C-like 1Kinase
10U302462.45.9Na/K/Cl transporterTransporter
11U273332.14α-1,3-fucosyltransferaseAdhesion
12Z713892.035.9Defensin β2Immunity
1M33680−68.9−27.6CD81Immunity
2J04152−49.9−7.8GA733-1Cancer antigen
3M86934−29.4−5.7GS1Unknown
4M97815−28.7−5.4Cellular retinoic acid-binding protein 2Squamous cell differentiation
5X82693−19.6−6.9E48Cancer antigen
6L05187−11.0−4.0SPRR1ASquamous cell differentiation
7X05908−9.5−6.8Annexin A1Squamous cell differentiation
8L33075−9.2−4.1IQGAP1Adhesion
9S37730−7.9−16.1IGFBP2aGrowth and metabolism
10L27943−7.6−4.6Cytidine deaminaseNucleic acid metabolism
11M19888−6.0−4.5SPRR1BSquamous cell differentiation
12X93510−5.5−12.237-kDa LIM domain proteinCandidate tumor suppressor gene
13M62402−4.8−11.7IGFBP6Growth and metabolism
14U40434−3.6−11.2MesothelinSquamous cell differentiation
15M18391−3.2−5.8EphA1Receptor tyrosine kinase
16X89986−3.2−5.4BikApoptosis
17Y07909−3.2−4.2Epithelial membrane protein 1Squamous cell differentiation
18M55210−4.5−4.5Laminin γ1Extracellular matrix
19U20499−4.3−4.3Sulfotransferase monoamine-preferringSulfate conjugation
20L24774−2.0−5.6Dodecenoyl-CoA δ isomeraseFatty acid metabolism
OCUM-2MLN
1X0310065.94.0MHC class II DP αAntigen presentation
2X0027413.610.7MHC class II DR αAntigen presentation
3M336009.38.5MHC class II DR β1Antigen presentation
4M135605.431.9Invariant chainAntigen presentation
5X627443.47.6MHC class II DM αAntigen presentation
1X53587−36.4−4.8Integrin β4Adhesion
2M58600−12.0−4.5Heparin cofactor IIProtease inhibitor
3L05187−11.6−4.6SPRR1 ASquamous cell differentiation
4M19888−5.6−4.7SPRR1 BSquamous cell differentiation
5X65614−2.0−41.4S100 PCalcium-binding protein
  • a IGFBP, insulin-like growth factor binding protein.