Table 2

Germline mutation, microsatellite status, and immunohistochemical analysis of hMLH1 and hMSH2 protein expression in ACF, adenomas (P), and carcinomas (K) of seven patients with HNPCC.

Patient no.Germline mutationType of lesionMSIhMLH1hMSH2
3NegativeACF+++
P1+++
P2+++
K+++
4hMLH1ACF++
P++
K++
5hMLH1P1++
P2++
P3++
K1++
K2++
6NegativeP1+++
P2++
K1+++
K2+++
K3+NTaNT
7hMSH2P++
K++
8hMSH2P++
K++
9hMLH1P++
K++
  • a NT, not tested.