Table 2

Distribution of XPD genotypes and DRC by case and control status

VariableCases n (%)Controls n (%)Crude OR (95% CI)Adjusted ORa (95% CI)
Total subjects341 (100)360 (100)
Lys751Gln
Lys/Lys 141 (41.3)159 (44.2)1.001.00
Lys/Gln 153 (44.9)162 (45.0)1.07 (0.78–1.46)1.07 (0.78–1.47)
Gln/Gln 47 (13.8)39 (10.8)1.36 (0.84–2.20)1.36 (0.84–2.20)
Trend testaP = 0.260P = 0.260
Asp312Asn b
Asp/Asp 102 (52.3)135 (52.5)1.001.00
Asp/Asn 72 (36.9)104 (40.5)0.92 (0.62–1.36)0.93 (0.63–1.39)
Asn/Asn 21 (10.8)18 (7.0)1.54 (0.78–3.05)1.51 (0.76–3.00)
Trend testaP = 0.517P = 0.535
Lys751Gln+ Asp312Asn
Both wild-type67 (31.5)105 (39.2)1.001.00
1 variant allele92 (43.2)116 (43.3)1.24 (0.82–1.87)1.28 (0.85–1.94)
2+ variant alleles54 (25.3)47 (17.5)1.80 (1.10–2.96)1.84 (1.11–3.04)
Trend testaP = 0.022P = 0.018
DRC (%)a
Proficient117 (65.7)183 (50.8)1.001.00
Suboptimal224 (34.3)177 (49.2)1.98 (1.46–2.68)2.00 (1.47–2.72)
  • a Obtained from the logistic regression model with adjustment for age (in yr), sex, and smoking status.

  • b Genotype data available for 195 cases and 257 controls.

  • c As described previously (4) .