Table 3

DRC (%) by XPD genotype

CasesControlsPb
nDRC, % (SD)PanDRC, % (SD)Pa
Lys751Gln
Lys/Lys 1418.21 (3.09)Ref.c1599.70 (4.26)Ref.c<0.001
Lys/Gln 1537.65 (2.73)0.1001629.33 (4.58)0.469<0.001
Gln/Gln 477.20 (2.27)0.041399.38 (5.25)0.6900.012
Trend testdP = 0.017P = 0.502
Asp312Asn e
Asp/Asp 1028.37 (3.26)Ref.c13510.34 (4.97)Ref.c<0.001
Asp/Asn 727.50 (2.53)0.0601049.33 (4.19)0.0970.001
Asn/Asn 216.84 (2.15)0.042189.78 (6.46)0.6660.058
Trend testdP = 0.008P = 0.190
Lys751Gln+ Asp312Asn
Both wild-type678.80 (3.14)Ref.c10510.00 (4.36)Ref.c0.052
1 variant allele927.65 (2.94)0.0121169.94 (5.05)0.925<0.001
2+ variant alleles547.23 (2.19)0.000479.20 (4.99)0.3190.010
Trend testcP = 0.001P = 0.409
  • a Two-sided t test for difference between genotypes.

  • b Two-sided t test for difference between cases and controls.

  • c Ref., reference value.

  • d From a general linear model.

  • e Genotype data available for 195 cases and 257 controls.