Table 4

XPD genotypes and risk for suboptimal DRC

GenotypesCasesControls
DRC (Poor/good)bORa (95% CI)DRC (Poor/good)bORa (95% CI)
Lys751Gln
Lys/Lys 93 /481.0074 /851.00
Lys/Gln 96 /570.85 (0.52–1.39)83 /791.22 (0.79–1.90)
Gln/Gln 35 /121.57 (0.74–3.35)20 /191.19 (0.59–2.42)
Trend testcP = 0.499P = 0.428
Asp312Asn
Asp/Asp 61 /411.0055 /801.00
Asp/Asn 47 /251.31 (0.68–2.51)49 /551.29 (0.77–2.18)
Asn/Asn 17 /43.50 (1.06–11.59)9 /91.48 (0.55–3.98)
Trend testcP = 0.046P = 0.269
Lys751Gln+ Asp312Asn
Both wild-type39 /281.0045 /601.00
1 variant allele58 /341.23 (0.63–2.39)51 /651.04 (0.60–1.78)
2+ variant alleles40 /142.29 (1.03–5.12)24 /231.41 (0.70–2.82)
Trend testcP = 0.048P = 0.393
  • a Adjusted for age, sex, and smoking status.

  • b Dichotomized at the median DRC of controls.

  • c Obtained from a logistic regression model adjusting for age, sex, and smoking status.