Table 2

Experimental details for rats given 4-NQO for 12 weeks followed by NIM for 14 weeksa

Group no.TreatmentNo. of rats (final)Body weight (g)·(final)Organ weight (g) (ratio to body weight × 10)Average water intakeAverage food intake
LiverKidneyWater (ml/day/kg body weight)4-NQO (mg/day/kg body weight)Diet (g/day/kg body weight)NIM (mg/day/kg body weight)
14-NQO alone11327 ± 399.1 ± 1.71.02 ± 0.0872.4 ± 19.92.23 ± 0.4042.3 ± 5.50
(27.6 ± 2.18)(3.15 ± 0.28)
24-NQO+ 150 ppm NIM12349 ± 3810.8 ± 2.31.12 ± 0.1074.2 ± 21.12.29 ± 0.4445.4 ± 5.16.8 ± 0.8
(29.7 ± 4.7)(3.24 ± 0.23)
34-NQO+ 300 ppm NIM13365 ± 2111.2 ± 0.91.16 ± 0.0873.1 ± 20.52.25 ± 0.4245.5 ± 5.413.6 ± 1.6
(30.7 ± 1.3)(3.20 ± 0.22)
44-NQO+ 600 ppm NIM12351 ± 4910.4 ± 2.41.12 ± 0.1372.2 ± 19.82.22 ± 0.3944.4 ± 5.630.0 ± 3.0
(30.4 ± 3.9)(3.24 ± 0.23)
5Water+ basal diet6388 ± 1512.5 ± 1.01.20 ± 0.0590.0 ± 24.5043.8 ± 7.60
(32.2 ± 2.5)(3.09 ± 0.14)
6Water+ 600 ppm NIM6392 ± 1311.2 ± 0.61.09 ± 0.0486.5 ± 22.5044.4 ± 6.526.0 ± 4.1
(28.7 ± 1.1)(2.77 ± 0.12)
  • a Values are means ± SD.